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The NIA-114™ Molecule in StriVectin-SD Products

Fight Deep Wrinkles, Crow's Feet and Stretch Marks

Discovered in skin cancer prevention research... patented NIA-114™+ Peptide Actives helps to rebuild skin layers.

NIA-114™ is the patented molecule found in StriVectin-SD® products. With its unique micronutrient delivery system, NIA-114™ penetrates the skin, delivers Niacin to the skin cells and enables healing from within to promote healthier, more beautiful looking skin.

Just as its name suggests, NIA-114™ is delivered from Niacin. Many are familiar with the oral form of Niacin, a water-soluble micronutrient found in a number of commonly eaten foods. As a nutritional supplements, Niacin aids in cholesterol reduction and energy metabolism. More recently, a topical form of it has emerged as a key factor in helping the skin protect and repair itself from sun damage and aging.

Structure
NIA-114™ resembles Niacin but differs in several very important ways.


1. NIA-114™ is the form of Niacin known as nicotinic acid.
Unlike nicotinamide, nicotinic acid stimulates the release of the hormone leptin, a natural repair hormone, that aids healing within the skin and aids in the reduction of hyperpigmentation.
(figure 1)

2. NIA-114™ contains what is known as a lipophilic tail.
The natural form of Niacin is hypophilic or “water loving” and therefore, cannot penetrate the lipophilic (fat-loving) skin barrier or stratum corneum. To be absorbed by the stratum corneum, the molecule must somehow be made lipophiliic. StriVectin®scientists have developed the molecule, NIA-114™ - a nicotinic acid molecule with an attached lipophilic tail, which CAN penetrate the lipid-rich outer layers of skin and diffuse into the sublayers of the epidermis where cellular regeneration and keratinization occur. (figure 2)

Delivery
NIA-114™ can be absorbed into the skin unlike other forms of Niacin.


Delivery of active ingredients across the skin barrier is a major challenge for all cosmeceuticals. StriVectin®’s NIA-114™ allows ingredients known to be beneficial to the skin to go beyond topical application and actually penetrate the epidermis. It does so in a slow, continuous release, allowing time for the molecule to bio-convert to its working form. This unique to the NIA-114™ molecule and is what distinguishes the StriVectin-SD ® from other products containing Niacin.

The skin barrier is made up of pancake-like cells with fatty or lipid matrix between the cells. In order to penetrate the lipid-rich stratum corneum and achieve the ultimate goal of reaching the substrata of the epidermis, the NIA-114™ molecule, with its lipophilic tail, crosses the skin barrier and slowly diffuses at an optimal rate into the sub-layers of the epidermis. As natural enzymes within the skin cleave the lipophilic tail, NIA-114™ converts back into nicotinic acid. Nicotinic acid is then bioconverted into the active molecule, NAD, which enters the skin’s cells and aids in various biochemical reactions. (figure 3)


Function
Increased levels of Niacin affect four major biochemical processes.


The result of these biochemical processes is the generation of healthier skin cells from the inside-out. The skin barrier is strengthened as a result of these improvements in the biochemical processes well below the skin’s surface.

Increased levels of Niacin affect four major biochemical processes:
1. Stimulate the repair of DNA.
DNA is your cell’s genetic code, which determine what cells will become and do. When your cells suffer damage from the sun or other environmental factors, this DNA can become altered. NIA-114™ helps stimulate the repair of DNA so your skin cells can undo some of he damage caused by the sun, creating healthier skin through a natural repair process.

2. Enhances energy metabolism and skin cell turnover.

Healthy skin cells need energy. The active from of Niacin, NAD, plays a crucial role in the energy metabolism of cells. Thus, by providing Niacin to the skin, healthy energy metabolism is promoted and skin cells can undergo proper cell turnover.

3. Promotes the release of leptin, a natural repair hormone.
Unlike its counterpart nicotinamide, nicotinic acid stimulates release of the hormone that promotes healing of the skin cells through wound repair and improved immune response as well as help to reduce hyperpigmentation through melansome transfer inhibition.

4. Stimulate a receptor that decreases hyperpigmentation.
Nicotinic acid stimulates a signaling cascade that inhibits the transfer of melanin from the melanocytes (cells that produce melanin) to the surrounding keratinocytes (other skin cells) such that hyperpigmentation is reduced.